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Ingredients in Totally Derma®


Collagen is an essential component in skin, providing integrity, firmness and elasticity. Collagen production is essential for supple, healthy, youthful looking skin and plays a crucial role in retarding the ageing process of skin.

10,000 mg. Arthred® Collagen Formula

Arthred®, is a patented, low molecular weight, pharmaceutical grade hydrolyzed collagen product, sourced via Gelita AG, the gelatine, collagen and collagen peptide experts. It is a free flowing (bovine sourced) pre-digested powder that is easily absorbed. It is made through a proprietary process that breaks down the collagen into tiny pieces: 3 kilo Daltons (kDa) for Arthred® vs. 70 kDa for a typical sports protein drink, where the molecules are just broken down into their constituent parts then eliminated.

1Clinically significant doses of regular gelatine typically cause gastrointestinal reactions precluding its usefulness for collagen & cartilage tissue support. Arthred®, by contrast, is extremely digestible and is well tolerated. It is therefore beneficial for individuals with a compromised digestive system.

Arthred® contains high amounts of amino acids, including glycine, proline, hydroxyproline and arginine. These amino acids have been linked to healthy bone and connective tissue, healthy skin appearance, tissue anabolism, normal metabolism and growth hormone secretion.


Hyaluronic Acid is a major component of the dermis and its fluidity. Hyaluronic Acid hydrates the skin and increases its volume and density whilst also supporting collagen and elastin within the skin.

Studies show older skin dramatically loses its ability to produce Hyaluronic acid thus resulting in skin with a loss of volume and formation of wrinkles and folds. Ingested Hyaluronic acid helps to restore the skin’s volume and promote a smooth, plump, natural appearance to the skin, thus filling wrinkles from the inside.

2HA is shown to have a durable effect to retain moisture in the skin from inside the body.(10) In a double-blind, 4 week study, individuals who added hyaluronic acid to their diet showed significant reductions in skin dryness, wrinkles, and improvements in skin moisture and fullness.

(Aesthetic Dermatology Vol.12 :109~120, 2002)

210 mg. Synovoderma HA

Totally Derma® contains SynovoDerma PATENTED Hyaluronic acid powder (HA). HA is a glycosaminoglycan (GAG) found in every tissue of the body, especially the synovial fluid, the cartilage, blood vessels, extracellular matrix and skin. Hyaluronic Acid hydrates the skin and increases its volume and density whilst also supporting collagen and elastin. SynovoDerma HA is prepared using a proprietary enzymatic process to reduce the molecular weight to between 50kDa – 200kDa Daltons.

CO-FACTORS Synergistic co-factors are also added to enhance and promote stages of collagen synthesis, repair, maintenance and prevention.

250 mg. Vitamin C is an essential component in the body’s production of collagen as it stimulates fibroblasts and converts proline to hydroxyproline. Vitamin C is scientifically shown to help maintain firm and youthful skin by combating collagen degradation and oxidative stress (it helps to repair ageing and photo-damaged skin)


160 mg. Grape Seed Extract is a very powerful antioxidant. It bonds to collagen and negates free radicals, boosts collagen development and helps in the renewal of skin cells. Grape Seed extract helps skin stay firm, supple and moisturized. Procyanidins found in Grape Seed Extract are also shown to protect and repair the skin from sun damage.

160 mg. Green Tea Extract is naturally rich in antioxidants and is associated with multiple skin benefits. It protects skin from the damaging effects of free radicals and also stimulates the skins microcirculation. It is a good anti-inflammatory for skin and most importantly inhibits collagenase (a natural enzyme that breaks down collagen). Numerous clinical studies show Green Tea Extract increases skin firmness, water content and elasticity. 

60 mg. Alpha Lipoic Acid is one of the MOST powerful antioxidants. Studies show it can slow down the ageing process of the body in general. Within the skin it reverses skin cell damage and is shown to improve fine lines and wrinkles. Alpha Lipoic Acid regenerates Vit C, Vit E and inhibits cross-linking which contributes to the formation of wrinkles.

5 mg. Zinc is an essential mineral for maintaining healthy, youthful skin. Zinc is well known for its properties in repairing UV damage in the skin and slowing down collagen degradation. Zinc is crucial for superoxide dismutase syntheses (protects against oxidative stress). Studies show it boosts Collagen synthesis and therefore helps to delay the formation of wrinkles.

3 mg. Manganese is also another essential mineral needed to build collagen and repair oxidative stress within the skin and body. Manganese strengthens immature collagen and influences its fibril size. The antioxidant effects of manganese have been shown to help prevent wrinkle formation and sagging skin.

0.33 mg. Copper is a metallic element that is a vital component in skin health. Copper deficiency is responsible for premature ageing and loose skin. Copper benefits skin health by repairing and maintaining connective tissue. Most enzymes that are responsible for collagen synthesis absolutely depend on copper as a co-factor; no other mineral can replace its role in stimulating collagen production.