TOTALLY DERMA is an Anti-Ageing Nutraceutical Skin Drink that works from the INSIDE to stimulate the body’s optimum production of collagen, elastin and hyaluronic acid, addressing both the aesthetic (physical) signs of ageing and the underlying physiological processes. Totally Derma is a DAILY ingestible skin drink for a double pronged approach to anti-ageing. Internal AND Topical.
TOTALLY DERMA Skin Drink is hypoallergenic and is formulated with the manufacturing quality standards set by the pharmaceutical industry. Totally Derma® Skin Drink contains scientifically proven bio-available ingredients. Drink it once a day (preferably at night) for a lifelong anti-ageing skin health investment.
TOTALLY DERMA Skin Drink contains 10,000 mg. of Arthred®, a Hydrolysed Collagen amino acid peptide and 210 mg. patented Hyaluronic Acid powder. Totally Derma Skin Drink is formulated with the highest quality and best absorbed nutritional components (including Vitamin C, grape seed extract, green tea extract and alpha lipoic acid) for the promotion of collagen synthesis and to repair, maintain and support skin volume, elasticity, density and hydration.
Hydrolysed means ‘pre-digested’, or in other words it is a molecular size that reaches the small intestine undamaged by digestive enzymes and is optimally absorbed there.
TOTALLY DERMA Skin Drink contains Arthred® hydrolysed collagen peptides, which is produced by enzymatic hydrolysis of collagen from the hides of German cattle under controlled conditions. Arthred® contains a highly bioavailable form of collagen. Clinical studies show 95% absorption. It is the tiny molecular size which is key to this absorption. The collagen in Totally Derma® Skin Beverage is 3 kdaltons, compared with around 70 kdaltons for most collagen supplements.
Because it is sourced from animal collagen, the amino-acid composition of the peptides resembles that of human collagen. This is different to collagen from marine and whey sources which have a different chemical structure.
TOTALLY DERMA Skin Drink has a high content of the amino acids, hydroxyproline and hydroxylysine as is characteristic of collagen. The predominant amino acids in Arthred® hydrolysed collagen – glycine, proline, hydroxyproline, lysine, and hydroxylysine – comprise approximately 50% of the substance, by weight. Clinical studies show that within an hour of consumption of Arthred, hydroxyproline, hydroxylysine, glycine, and proline all rise considerably. With Hydroxyproline (being the main component of collagen fibres) rising an impressive 550%. These amino acids are transported to collagen containing tissue such as skin, hair, cartilage and bone and stimulate collagen production.
Arthred®’s origin is a Pharma-grade, physiological product for joint health. This does not mean that Arthred only stimulates collagen type II for cartilage (which it does) it is also shown to promote collagens type I & IV which obviously benefit skin. (4)
Arthred® differs from other hydrolysed collagens by being processed through a proteolytic enzymatic hydrolysis process under controlled conditions. This means the proteolytic enzymes facilitate the cleavage of the amino acid peptide bonds. Whereas most other hydrolysed collagens on the market are just hydrolysed through a water process alone. The benefits of an enzymatic hydrolysis are smaller short chain amino acid peptides which are uniform and consistent in size thereby guaranteeing a 95% absorption rate.
Most collagen producers do not hydrolyse with proteolytic enzymes as the process takes much longer than standard hydrolysis (up to 6 hours per batch), this makes the process expensive and time–‐consuming, but it definitely yields the most superior form of hydrolysed collagen.
A good functioning, normal digestion breaks down protein into peptides (within the stomach) and short chain amino acids (within small intestine) which are then absorbed into the bloodstream.
For the collagen protein found in foods and most supplements to be utilized by the body, it must first be broken down many times by the digestive system, and then absorbed through the intestine into the blood in the precise form needed. It is then reassembled into collagen at the proper site needed. However, for most people, protein digestion of dietary collagen is often incomplete, resulting in some very large peptide chains. These long molecules are not well absorbed and often remain undigested in the intestines and finally excreted via the bowel.
Arthred’s guaranteed small short chain amino acid content, takes the burden off the digestive system. The product is deemed as “pre-digested” as it is already in the form needed for straight absorption through the small intestine – therefore the stomach does not need to break it down. This is particularly useful in clients who have compromised digestive systems as the protein in Arthred® does not need to be broken down by the digestive system.
Hyaluronic Acid is a major component of the dermis and its fluidity. Hyaluronic Acid hydrates the skin and increases its volume and density whilst also supporting collagen and elastin within the skin.
TOTALLY DERMA Skin Drink supplies an optimal 210 mg. (per serving) of patented Hyaluronic Acid powder which uses a proprietary enzymatic process to enhance absorption through the digestive tract to 95%. This enzymatic process reduces the molecular weight of the HA in Totally Derma® from 1,500 kdaltons to only 50 kdaltons. Again, like Arthred® the tiny molecular size is key to its 95% absorption.
Studies show older skin dramatically loses its ability to produce Hyaluronic acid thus resulting in skin with a loss of volume and formation of wrinkles and folds. Ingested Hyaluronic acid helps to restore the skin’s volume and promote a smooth, plump, natural appearance to the skin, thus filling wrinkles from the inside.
Researchers at Toho University have found ingested Hyaluronic Acid supplementation to be directly correlated to measured increases in skin moisture, increased skin smoothness, and amelioration of wrinkles. A double blind study was carried out wherein 35 subjects ages 30-60, who frequently suffer from dry, rough skin, were given either a dietary hyaluronic acid supplement with the same patented process as Totally Derma Skin Drink, or a placebo over a 4-week period. The results showed that the group who had ingested Hyaluronic Acid had a significant increase in skin moisture. Microscopic skin surface analysis also showed an increase in skin smoothness and lessening of wrinkles. (2) Another placebo-control double-blind study supplementing 22 individuals with the same patented Hyaluronic Acid found in Totally Derma® Skin Drink, showed over a 6-week period improvements in dryness, itchiness, redness, damage due to cosmetics, erosion and exfoliation. Microscopic, 3-dimensional skin surface analysis also showed improvement in skin smoothness. (3)
Collagen is an essential component in skin, providing integrity, firmness and elasticity. Collagen production is essential for supple, healthy, youthful looking skin and plays a crucial role in retarding the aging process of skin. Approximately 80% of young and healthy skin is made up of collagen (type I). However, our skin gradually loses the ability to regenerate naturally and produces less collagen in our mid-30s. Around 35 and 55 years of age, the level of collagen drops to 40% resulting in the loss of firmness and the formation of wrinkles.
The collagen included in the formulation of TOTALLY DERMA has been enzymatically hydrolysed, or pre-digested, to ensure fast absorption in the small intestine within an hour, before entering the blood vessels, thereby facilitating its optimum body utilisation. Studies of radio-labelled high-quality bovine collagen peptides show that, once absorbed, collagen peptides are distributed throughout all areas of the body – not only in the joints but also in the skin, demonstrating that high-quality collagen can be efficiently absorbed where needed, and that it is not wasted or lost through urine. Collagen and HA work together to stimulate each other’s production through a positive feedback mechanism: the more collagen that is present, the more HA is produced, and HA itself stimulates fibroblast cell growth within the collagen matrix of the dermis, which in turn will promote further collagen production.
A study of six fresh animal skin samples was examined from different groups. The study showed that after 4 weeks of daily ingestion, Animal Hydrolysed Collagen resulted in a significant increase of type 1 & 4 collagen syntheses in skin (up to FOURFOLD). Skin fibroblasts were also shown to increase in volume and activity. Fibroblast cell cultures showed a high percentage of cells in the S phase than the control cells and decreased percentage of cells in apoptosis compared with controls. Also after 4 weeks of CH ingestion significantly decreased MMP2 activity was noted compared with the other 2 groups. (These are cells that degrade skin collagen, cause skin aging & wrinkles) (4)
Hyaluronic Acid is a major component of the dermis and its fluidity. Hyaluronic Acid hydrates the skin and increases its volume and density whilst also supporting collagen and elastin within the skin.
TOTALLY DERMA Skin Drink supplies 210 mg. (per serving) of patented Hyaluronic Acid powder which uses a proprietary enzymatic process to enhance absorption through the digestive tract.
Studies show older skin dramatically loses its ability to produce Hyaluronic acid thus resulting in skin with a loss of volume and formation of wrinkles and folds. Ingested Hyaluronic acid helps to restore the skin’s volume and promote a smooth, plump, natural appearance to the skin, thus filling wrinkles from the inside. Synergistic co-factors including Vitamin C, grape seed extract, green tea extract and alpha lipoic acid are also added to enhance and promote stages of collagen synthesis, maintenance, promotion and repair.
Why do you have 7 co-factors in Totally Derma® Skin Drink?
A co-factor is a chemical compound which is required for a biological reaction. TOTALLY DERMA Skin Drink co-factors are ‘synergistic ingredients’ that play an important role in healthy collagen synthesis and repair.
Although Arthred® enzymatically hydrolysed collagen and hyaluronic acid are key nutrients for stimulation of collagen synthesis and skin hydration, these other nutrients also play a role in maximizing their effects.
Ascorbic Acid (known as Vitamin C) has been shown to increase collagen synthesis in cultured skin fibroblasts by approximately 8-fold. Studies suggest that collagen polypeptide synthesis and the activity of hydroxylases are independently regulated by ascorbic acid. (12)
Ascorbic acid is an essential cofactor for lysyl hydroxlase and prolyl hydroxylase, the enzymes needed for collagen biosynthesis. If a patient is Vitamin C deficient then these enzymes cannot function and hydroxyproline and hydroxylysine will not be produced. Ascorbic acid is also shown to stimulate collagen-specific mRNA for collagen synthesis. (13)
In cell culture models, vitamin C supplementation has many beneficial effects in combating photo damage. Specifically, vitamin C has been shown to stabilize collagen mRNA, thus increasing collagen protein synthesis for repair of the damaged skin (14).
Oral supplementation with vitamin C effectively increases vitamin C levels in the skin (15 & 16)
Copper is also essential for healthy collagen and elastin production. Studies clearly show that the synthesis of mature elastin and collagen take place and are controlled by the availability of copper.
A lack of copper can induce defective crosslinking of collagen and elastin. This can cause problems such as premature ageing and wrinkling of the skin. Oral supplementation of copper increases lysyl oxidase activity. (17)
Copper is an important cofactor for the activation of lysyl oxidase and regulates lysyl oxidase synthesis, this is the only enzyme involved in collagen crosslinking.(18) Supplementation of oral copper increases lysyl oxidase within 4-6 hours, this continues to increase activity even after 20 hours after copper administration. (19)
Manganese is required for the activation of prolidase, an enzyme that functions to provide the amino acid, proline, for collagen formation in human skin cells. Orally ingested Manganese is therefore essential in the synthesis of skin collagen and is also beneficial for optimal wound repair. (20)
Manganese is also an essential cofactor for the glycosylation of hydroxylysine. The glycosylation step strengthens the characteristics of the newly formed collagen molecule and also influences its fibril size. This is a vital step for optimal healthy production of collagen. Glycosylation enzymes are found with the highest activity in the young and decrease as we age. (21 & 22)
Zinc is vital to the functioning of more than 300 hormones and enzymes in the body.
Zinc’s involvement in collagen synthesis is mainly through two different enzymes, procollagen N-proteinase, and procollagen C-proteinase. These two enzymes are required for processing the soluble precursor (procollagen) to collagen and they cannot function without zinc.
Various animal studies show zinc deficiency results in a significant reduction in collagen synthesis and turnover. (23 & 24)
Oral Zinc supplementation, due to its involvement in collagen synthesis, is shown to benefit post surgery trauma and wound healing (25)
Zinc is also useful in combating oxidative stress within the body and skin. It is an essential cofactor for superoxide dismutase (SOD), an antioxidant enzyme associated with longevity and protection against oxidative stress. (26)
Skin is a major target of oxidative stress due to various damaging elements in the outer environment (such as UV damage & pollutants) and various processes within skin itself (such as aging & exercise). The most major contributor to skin ageing and wrinkling is oxidative stress. Therefore, Zinc can be a useful component in skin anti-ageing. (27)
Oral zinc supplementation is shown to scavenge free radicals and increase the activity of SOD and Glutathione Peroxidase within the body (28)
GRAPE SEED EXTRACT
Grape Seed Extract is known as a powerful antioxidant that protects the body from premature ageing, disease, and decay. Grape seeds contain mainly phenols such as proanthocyanidins. Research suggests that grape seed extract is beneficial in many areas of healthy skin because of its antioxidant effect to bond with collagen, promoting youthful skin, cell health, elasticity, and flexibility. Studies have also shown that oral Grape Seed Extract helps to protect tissue from free radicals, sun damage and inflammation. (29)
GREEN TEA EXTRACT
Studies show that Green Tea Catechins (Catechins are the active polyphenol in green tea) are able to improve skin characteristics, including elasticity, roughness, scaling, density, and water content. Additionally, less UV radiation damage is also noted with green tea catechins. Studies also show that oral green tea extract boosts oxygen flow to the skin, this peaks 30 minutes after ingestion. When skin circulation is improved, skin health is also improved. In summary, green tea polyphenols delivered in a beverage have been shown to protect skin against harmful UV radiation and help to improve overall skin quality. (30)
ALPHA LIPOIC ACID
Alpha Lipoic Acid is a water- and fat-soluble antioxidant that is capable of regenerating other antioxidants, such as vitamins C and E. It therefore exerts numerous anti-aging effects in the body and skin which assists in repair and maintenance. (31)
Alpha lipoic acid research done on human dermal fibroblasts in vitro (test tube) in cell-culture systems show that, when taken orally, Alpha Lipoic Acid helps to prevent cellular damage via its antioxidant properties. By protecting fibroblasts (the cells which produce collagen in the skin) this helps to slow down the ageing process in the skin and stimulate repair. (32)
Each daily dosage of TOTALLY DERMA Skin Drink contains a therapeutic dosage of 10,000 mg of hydrolysed collagen peptide powder and 210 mg. of hyaluronic acid (amino acid) powder. Totally Derma® is of the highest quality and purity obtainable, is free of all common allergens, and does not contain preservatives, diluents, or artificial additives.
Mix one level scoop of powder into a full glass of juice or water once a day at night (though it can be taken in the morning. Do not exceed the recommended daily dosage.
£3.26 per day. Same cost as your Latte each day.
£98.00 for a 30-day supply.
It tastes very pleasant, with a hint of vanilla.
No detrimental side effects have been observed. TOTALLY DERMA is very gentle and well tolerated in the gut, therefore it can also be consumed by those with a compromised digestive system.
TOTALLY DERMA is manufactured by Allergy Research Group who were one of the first to introduce truly hypoallergenic products to the market.
Arthred® COLLAGEN (being bovine) does not have common allergenic potential like other collagen/protein supplements which tend to be whey, soy, marine based.
A quote from the manufacturer:
Since our inception in 1979, we have used only the purest, and whenever possible, the lowest allergy potential natural ingredients. And while many of the nutrients in our formulas are synthesized from natural plant substances, which as a whole may contain antigens, the synthesizing process removes the molecules of the desired nutrient from the original substance, and in the processing, a great percentage of the antigens and allergens are left behind. The final material then has extremely low allergy potential. This is not to say that no one will react to any of our hypoallergenic formulas, as some extremely sensitive people may. However, the potential for an allergic reaction is low, and the feedback from many of our extremely allergic and sensitive customers is that Allergy Research Group® supplements are often the only products they are able to tolerate.
No, it contains hydrolysed collagen derived from a bovine source.
TOTALLY DERMA does not contain significant levels of insulin raising sugars; it is, therefore, safe for people with diabetes to consume at the stated daily dose. If in doubt, please contact your medical professional.
If you are unsure, it is best to check with your doctor, pharmacist or a healthcare practitioner.
Skin biopsy studies show that after 4 weeks of daily ingestion, the animal collagen in Arthred increases collagen synthesis up to FOURFOLD. Skin fibroblasts are also shown to increase in volume & activity. MMP2 activity is also shown to be significantly reduced (this degrades skin collagen) (4)
This unique formulation contains a superior form of hydrolysed collagen, Arthred®, sourced via Gelita, AG, the collagen peptide experts. Arthred® hydrolysed collagen is enzymatically processed, resulting in its UNIFORM, pharma grade, low molecular size (3 kDa) which allows for a scientifically-proven 95% absorption rate, this far exceeding regular collagen supplements (which average a larger size of 70kDa and therefore are less easily absorbed).
While most hyaluronic acid supplements are poorly absorbed and are minimally effective, the formulation of TOTALLY DERMA also includes SynovoDerma® hyaluronic acid which has been processed to enhance absorption for maximum benefits. These two key ingredients ensure the impressive increase of collagen and hydration in the skin, as shown by results of two clinical studies: 10-weeks and 12 weeks – for the formulation.
Arthred® hydrolysed collagen is produced by enzymatic hydrolysis of collagen from the hides of German cattle under controlled conditions.
Arthred® is quality control tested and is assured to be within safe limits for contaminants, such as moulds, yeast, bacteria and heavy metals. A 1973 literature review showed that hydrolysed collagen does not contain antigens that can cause anaphylaxis (unlike Marine Collagen). Hydrolysed collagen is considered a food substance and has GRAS (Generally Recognized as Safe) status. (6 & 7)
Germany, as well as the World Health Organization (WHO), has regulations in place that prohibit both the use of growth hormones in raising cattle and the importation of beef products that come from cows raised with them. Germany also prohibits the importation of beef and beef products from the United Kingdom and any country that has identified mad cow disease among its animal population. Because of this, one can be certain that absolutely no animals containing growth hormones are used in the production of Arthred®.
Furthermore, the material is produced to meet pharmaceutical standards that require a level of purity at which no growth hormone, pathogen or toxin can be left in the material after processing, even if they were initially present in the animal. This fact has been experimentally tested and proved by the supplier of the gelatin collagen, Gelita AG in Germany. Veterinary certificates are also produced regularly to prove Arthred®’s origin and purity.
As Arthred® is made from Gelita Gelatin it contains the same ratio of proteins as gelatin. Characteristic features of gelatin are the high content of the amino acids glycine, proline, & hydroxyproline – these are all essential in collagen production.
Diagram of Gelatin Amino Acid Composition
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